Data Input

Table of Contents

There are two mandatory and one optional inputs for mFABIO to perform multi-tissue TWAS fine-mapping on a binary trait of interest. Example data can be loaded within the mFABIO R package:

    library(mFABIO)
    data(example_data)

1. Predicted GReX of the TWAS cohort at gene-tissue pair level #

  • An example R matrix can be loaded like this: 
    G <- example_data$G

2. Binary phenotype of the TWAS cohort #

  • An example R vector coding case as 1 and control as 0 can be loaded like this: 
    y <- example_data$y

3. Corresponding genotypes of the cis-SNPs in the region of interest (optional) #

  • This input is optional, and you can include it when considering the pleiotropic effects. An example R matrix can be loaded like this: 
    X <- example_data$X